Adherens junctions are mechanically dynamic structures that link the actin cytoskeleton of neighboring cells through cadherin–plaque complexes. Their stability plays a critical role in maintaining tissue integrity under mechanical stress.

黏著連結是一種具有機械動態特性的細胞結構，透過鈣黏蛋白與斑塊複合體， 將相鄰細胞的肌動蛋白骨架連結在一起， 在組織承受張力時維持整體穩定性。

Their function is highly sensitive to intracellular tension, actin polymerization, and signaling pathways that regulate cytoskeletal remodeling.

黏著連結的功能高度依賴細胞內張力狀態、肌動蛋白的聚合動態， 以及調控細胞骨架重塑的訊號路徑。

Actin microfilaments associated with adherens junctions continuously adapt to mechanical forces generated during peristalsis, skin stretch, or tissue repair.

與黏著連結相連的肌動蛋白微絲，會持續因應蠕動、皮膚牽拉， 或組織修復過程中所產生的機械力而進行調整。

Excessive inflammatory signaling or autonomic dysregulation may alter actin organization, weakening junctional stability.

過度的發炎訊號或自律神經失衡， 可能改變肌動蛋白排列，進而削弱黏著連結的穩定性。

Cadherins function not only as adhesion molecules but also as mechanosensors that respond to changes in intercellular tension.

鈣黏蛋白不僅是細胞黏附分子， 同時也是對細胞間張力變化高度敏感的機械感受器。

Altered cadherin signaling has been associated with impaired epithelial integrity and abnormal tissue remodeling.

當鈣黏蛋白的訊號調控出現異常時， 可能導致上皮完整性下降與組織重塑異常。

From a modern physiological perspective, acupuncture is understood as an indirect regulatory intervention that modulates neural, immune, and mechanical environments rather than directly altering junctional proteins.

從現代生理學角度來看，針灸被理解為一種「間接調節」方式， 透過影響神經、免疫與力學環境， 而非直接改變黏著連結本身的蛋白結構。

Reported effects include modulation of autonomic tone, reduction of pro-inflammatory mediators, and improvement of local microcirculation— all factors that may influence actin dynamics and cadherin-mediated tension balance.

研究顯示，針灸可能調節自律神經張力、降低促發炎介質、 並改善局部微循環， 這些因素皆可能影響肌動蛋白動態與鈣黏蛋白介導的張力平衡。

In this context, acupuncture is best understood as a supportive intervention that helps restore a physiological milieu favorable to stable cell–cell adhesion under mechanical stress.

在此脈絡下，針灸可被視為一種支持性介入方式， 協助恢復有利於細胞在機械壓力下維持穩定黏附的生理環境。

This interpretation emphasizes systems-level regulation rather than molecule-specific targeting.

此理解強調的是系統層級的整體調節， 而非單一分子層面的直接作用。

From a Traditional Chinese Medicine perspective, tissue stability and coordinated movement are described through the functional regulation of Ying and Wei systems.

從中醫理論角度來看，組織的穩定性與協調性， 常以營氣與衛氣的功能性調節來理解。

Ying is associated with nourishment and structural maintenance, whereas Wei is associated with protection, rapid response, and dynamic tension regulation at body interfaces.

營氣偏向滋養與結構維持； 衛氣則偏向防禦、快速反應， 以及體表與介面層級的動態張力調節。

The Luo network describes fine-scale pathways that distribute regulatory signals beyond primary meridian axes, comparable at a functional level to microstructural force and signal transmission systems.

絡脈系統描述的是在主要經脈之外， 負責精細分布調節訊號的網絡， 在功能層級上可類比為組織中的微結構力學與訊號傳遞系統。

This article is for educational purposes only and reflects an integrative, physiology-based understanding.
本文為學術與衛教整合內容，非醫療診斷或治療建議。